In liver cirrhosis, the mechanical transduction pathway RhoA/ROCK was activated and led to increased vascular contractility and portal pressure (Hennenberg et al., 2006; Trebicka et al., 2007), moreover, the matrix stiffness-induced RhoA overexpression also interacts with the cytosolic tyrosine kinase c-SRC and decreases the c-SRC activity to activate HSC to mediate liver cirrhosis (Görtzen et al., 2015). Here, RHOA is linked to cirrhosis of liver.