Consistent with literature reports, the intercellular junction complexes which ensure the integrity of the epithelial barrier and regulate paracellular permeability, including Occludin, ZO-1 (Camara-Lemarroy et al., 2018), located around the apical surface of adjacent epithelial cells, were significantly decreased in EAE mice and reversed by OMAT treatment, and the regulatory effect of OMAT on the IEB or BBB function in EAE model mice was also confirmed in DSS model mice (Yao et al., 2021) or early brain injury rats (Liu et al., 2016). The gene discussed is TJP1; the disease is injury.