Some studies also found that the abundance of Ruminococcaceae decreased in infants with eczema, and inflammatory cytokines such as IL-6 and TNF-α increased, and a decrease in the number of Ruminococcus can induce a toll-like receptor inflammatory response (Arshi et al., 2014; West et al., 2015). This evidence concerns the gene TNF and Eczematoid dermatitis.