SLC1A2 and ischemic stroke: In vitro and in vivo (Weller et al., 2008) experiments have demonstrated that upregulation of GLT-1 in astrocytes by ceftriaxone (Ouyang et al., 2007) or adenoviral vectors (Harvey et al., 2011) could reduce the area of cerebral infarction, attenuate neurological impairment, and offer neuroprotective effects against ischemic stroke.