Different species of GABACeA neurons, including those expressing adrenocorticotropin-releasing hormone (CRH), protein kinase C delta (PKCδ), somatostatin (SOM), and neurohypophysin (Duvarci and Pare, 2014; Kim et al., 2017; McCullough et al., 2018), may have different roles in pain and anxiety regulation (Wilson et al., 2019; Adke et al., 2021). This evidence concerns the gene CRH and Anxiety.