NAV1 and neuroblastoma: Nav2 is necessary for neuritogenesis in neuron-like SH-SY5Y cells (Muley et al., 2008; Marzinke et al., 2013), and Nav1 is necessary for neuritogenesis in multiple systems, including neuroblastoma cells and primary hippocampal neurons (van Haren et al., 2014; Powers et al., 2022).