One binding partner identified in N1E mouse neuroblastoma cells is Trio (van Haren et al., 2014), a Rho and CDC42 guanine exchange factor (GEF) that regulates actin dynamics via the Rho/Rac pathway and is important in neurite outgrowth (Estrach et al., 2002; Briançon-Marjollet et al., 2008). Here, RHO is linked to neuroblastoma.