Polarization of macrophages toward a proinflammatory phenotype, which produces high levels of IL-2, IL-23, IL-6, IL-1β, and TNFα, is strongly associated with atherosclerosis, whereas proresolving macrophages, which produce large amounts of IL-10 and Transforming growth factor beta (TGFβ) as well as expressing scavenger receptors, mannose receptors, and arginase 1 (Arg1), have been linked to atherosclerosis regression [11–15]. The gene discussed is IL1B; the disease is atherosclerosis.