Diabetes and cardiology outpatient clinics at the Hospital of Southern Jutland Region: USA Age: ≥ 65 years Inclusion: HT (treated with ≥ 2 antihypertensives) and DM (treated with any antidiabetics or insulin) Exclusion: on OAC, EF < 45%, valvular disease needing intervention, implanted PM/ICD, known ischemic heart disease, ST/TIA, PAD, thyrotoxicosis, end-stage renal failure, severe obesity Known AF: excluded. The gene discussed is INS; the disease is coronary artery disorder.