Beyond the embryonic transcription factors OCT4, NANOG, and putative miR-1305 interference, POLR3G expression is also regulated by MYC and sensitive to MYC disruption in cancers featuring MYC upregulation, including colon carcinoma and acute myeloid leukemia cell lines (Renaud et al., 2014; Van Bortle et al., 2022). Here, POLR3G is linked to acute myeloid leukemia.