RPA1 and Neurodevelopmental delay: When bound to the parental ssDNA at forks, RPA can promote stalled fork reversal, which is a prerequisite for NDD (Bhat and Cortez, 2018; Berti et al., 2020), while nascent ssDNA-bound RPA participates in resection of this DNA (Soniat et al., 2019; Duan and Pathania, 2020).