While STING still can, in principle, exert its effect on NDD indirectly, detection of STING-dependent ssDNA/RPA responses, and of STING presence in the chromatin/NE fractions (Figures 1, 4, Supplementary Figures S1, S3) together with the Dixon et al. (2021) report of the inner nuclear membrane (INM) pool of STING, argue for nuclear involvement of STING. This evidence concerns the gene RPA1 and Neurodevelopmental delay.