We performed serial extraction of nuclei of WI38hTERT fibroblasts and compared STING partitioning to that of cGAS and other known self-DNA sensors—IFI16, DNA-PK, MRE11—that interact with STING and/or are relevant to the cGAS/STING pathway activity as well as function in DNA repair and/or in NDD (Schlacher et al., 2011; Ferguson et al., 2012; Ying et al., 2012; Ying et al., 2016; Morchikh et al., 2017; Coquel et al., 2018; Dunphy et al., 2018; Cheradame et al., 2021; Ka et al., 2021). This evidence concerns the gene IFI16 and Neurodevelopmental delay.