Malik et al. (2014) observed an effect of STING on chromatin compaction. We propose that the INM STING associates with chromatin in the context of lamina/chromatin complexes. This context provides ample opportunities for STING to affect NDD, since lamins and lamin-associated proteins are extensively implicated in the regulation of replication fork metabolism [reviewed in (Graziano et al., 2018; Willaume et al., 2021)], including but not limited to the recruitment of RPA (Graziano et al., 2021; Bao et al., 2022) (Figure 8C). Here, RPA1 is linked to Neurodevelopmental delay.