CD40LG and COVID-19: Here, we aimed to evaluate the clinical performance of the BioIC SARS-CoV-2 immunoglobin (Ig)M/IgG detection kit for detecting IgM and IgG antibodies against SARS-CoV-2, particularly with respect to the VOC Omicron (B.1.1.529) lineage, which is driving the fourth wave of the Taiwan COVID-19 epidemic.