CD274 and neoplasm: It is well-documented that RCT suppresses tumor growth and modulates anti-tumor immunity in various cancers.6,7 In patients with CC, studies of bulk RNA-sequencing of immune cells have shown that RCT stimulates the expression of the co-stimulatory molecule CD288 and downregulates the expression of inhibitory molecules PD-1/PD-L1.9 At the same time, multispectral flow cytometry of cervical smears revealed an early decrease in the number of T cells in the RCT-treated cervical TME, followed by an increase in their number at a later stage.