However, a recent study has demonstrated that blocking the recruitment of naïve CD4+ T cells can reverse the immunosuppression by Treg.42,43 Further, that study showed that the abundance of naïve CD4+ T cells and Tregs was closely correlated and that both indicated a poor prognosis for patients with breast cancer.42 Thus, targeting naïve CD4+ T cells may enhance the efficacy of RCT in CC, which is a possibility warranting further investigation. This evidence concerns the gene CD4 and breast cancer.