Studies of human small-cell lung cancer, neuroblastoma, and Merkel cell carcinoma claim that MHC-I alone is vital for the presentation of endogenous antigen by cancer cells to CD8+ cytotoxic T cells, suggesting that tumor elimination mainly depends on CD8+ cytotoxic T cells.33 We identified, for the first time, the upregulated expression of genes encoding MHC-II in epithelial cells of patients with CC undergoing RCT, which was expected to markedly enhance their immunogenicity. This evidence concerns the gene CD8A and Merkel cell skin cancer.