NCR1 and sarcoma: Using cells from a patient-derived xenograft model in dogs and a canine sarcoma model, Canter et al. showed that radiotherapy could enhance NK cell (CD56dim, NKp46+) cytotoxicity ex vivo.41 In conclusion, RCT seems to have an effect on the TME of CC, potentially regulating the composition of immune cells, including markedly increased frequency of CD16+ NK cells, which could augment the anti-tumor response.