Two cell subclusters showed a notably pro-tumoral potential: APOE_Mac highly expressed the C1Qs complement gene, implying its role in efferocytosis, which may promote immunosuppressive TME;18 whereas CCL20_Mac expressed genes encoding immunosuppressive chemokines, such as CCL20 and CXCL8. 19,20 In contrast, cells within the IFIT2_M-MDSC cluster predominantly expressed pro-inflammatory genes, such as IFIT2 and CXCL10, which may promote anti-tumor immunity. This evidence concerns the gene IFIT2 and neoplasm.