To address if BMI of the breast cancer patients could be related to the de-differentiation processes in the breast cancer tissue, as indicated in Table S4, 32 breast cancer samples classified as T3/T4 from 16 lean- (BMI ≤ 25) as well as from 16 patients with obesity (BMI ≥ 35) were stained for LIF (iCAF) and αSMA (myCAF) by immunochemistry and evaluated with the weighted score [63]. The gene discussed is ACTA1; the disease is obesity due to melanocortin 4 receptor deficiency.