LGR5 and cancer: ob-aT bASCs exhibited an increased ability to stimulate cancer stemness in highly malignant MDA-MB-231 cells by enhancing the gene expression of pluripotency and CSC associated genes such as ALDH1H1, ALDH2, c-MYC, CD34, LGR5, CXCR4, SOX2 and OCT4 [62, 93], fueling further their malignant potential.