E2F1 and obesity due to melanocortin 4 receptor deficiency: Of importance, like ln-aT bASCs, ob-aT as well as ob-dT bASCs display enhanced E2F1. ob-dT bASCs differentiate less efficiently than ln-dT bASC, strengthening the negative impact of obesity on the differentiation capacity of MSCs in various adipose tissue types [9, 74].