APOE and aortic aneurysm: Consistent with the findings of previous studies, continuous infusion of ApoE-KO mice with Ang II for 4 weeks induced AAA development in the suprarenal aorta, as shown in Fig. 2B. Hyperuricemia markedly enhanced the aortic aneurysm severity, as reflected by the maximal abdominal aortic diameter (control, 0.66 mm; hyperuricemia, 0.88 mm; Ang II, 1.22 mm; and hyperuricemia + Ang II, 2.07 mm; n = 10, respectively; P < 0.05; Fig. 2C).