The uric acid- and potassium oxonate-treated mice developed hyperuricemia, and their serum uric acid levels were significantly different from those of the untreated mice (control, 2.15 mg/dl; hyperuricemia, 5.18 mg/dl; Ang II, 2.46 mg/dl; and hyperuricemia + Ang II, 6.2 mg/dl; P < 0.01; Fig. 2A). This evidence concerns the gene AGT and hyperuricemia.