Hence, the aim of this paper was to recalculate the optimal minimum lymph node count for colon cancer patients with CEA-elevated (≥ 5 ng/ml) disease [13], with data from the Surveillance, Epidemiology, and End Results (SEER) program and the Second Affiliated Hospital of Harbin Medical University. This evidence concerns the gene CEACAM5 and malignant colon neoplasm.