To confirm the role of fatty acid metabolism disturbance in the progression of psoriasis, we administered oleic and stearic acids to K14-VEGF mice and IMQ-treat mice, and found that this aggravated psoriasiform skin inflammation by increasing Th17 cell differentiation in DLNs as well as increasing Th17 and moDDC infiltration in the skin. This evidence concerns the gene VEGFA and psoriasis.