KRT14 and psoriasis: To determine the role of intestinal microbiota in the pathogenesis of psoriasis, gentamicin was used to reduce the abundance of Prevotella. This intervention alleviated the pathogenesis of psoriasis-like symptoms in K14-VEGF mice and IMQ-treat mice, including skin inflammation, Th17 infiltration in skin, and Th17 differentiation in DLNs by reducing the abundance of Prevotella and increasing the abundance of Parabacteroides distasonis.