Our results showed that administration of gentamicin alleviated pathogenesis of psoriasis-like symptoms, including alleviating psoriasiform skin inflammation, a decrease in the skin epidermis thickness, decreasing mRNA expression of IL-17A, IL-23, S100A7, and increased mRNA expression of KRT10 (Supplementary Fig. 6a–i). This evidence concerns the gene IL37 and psoriasis.