Oleic acid and palmitic acid were reported to activate DCs, stimulate IL-23 secretion, enhance Th17 cell responses, and increase IL-17 expression in vitro.38 To explore the role of fatty acids in the regulation of psoriasis, 2 M mice were administered with either oleic and stearic acids (treated group) or PBS (control group). The gene discussed is IL17A; the disease is psoriasis.