TNF and obesity due to melanocortin 4 receptor deficiency: Obesity accelerates inflammation because adipose tissue produces proinflammatory adipokines (eg, TNF-alpha, IL-6, monocyte chemoattractant protein-1, resistin, and leptin),14,15,17 which are directly involved in atherosclerosis.16 In line with the rapid increase of obesity worldwide in the past decades,18 cardiometabolic diseases due to obesity are an ongoing major public health burden.