Another one is aberrant tumor angiogenesis caused by the high amount of pericytes coverage on tumor vessels, which improves tumor vessel stability and perfusion, thereby ensuring the delivery of nutrients to support tumor growth and preventing tumor cell dissemination through blood vessels.[28, 29, 30] In addition, THY1 was found functioning as both cancer stem cell and CAF marker in ESCC in our previous study.[31] Thus, THY1+PDGFRβ+ pericyte maybe function as a subset of CAF possessed pluripotent potential in promoting ESCC lymph node metastasis. This evidence concerns the gene PDGFRB and cancer.