CXCR4 and cancer: Gene set enrichment analysis (GSEA) analysis of differentially expressed genes between C16 and other subclusters revealed that tumor necrosis factor alpha (TNFA)‐signaling via nuclear factor kappa‐B (NFKB) and inflammatory response pathway is enriched in primary malignant C16 epithelial cells while the interferon response pathway was enriched in lymph node metastasis C16 epithelial cells (Figure 5j), consistent with previous reports that the CD74‐MIF‐CXCR4 axis is involved in inflammatory and atherogenic immune cell recruitment, stem cell homing, and cancer cell metastasis.[32, 33, 34]