Intriguingly, interferon‐induced T cells are only existing in metastatic lymph node and their highly expressed IFIT1/IFIT3 genes have been associated with tumor growth, regional, and distant metastases in oral squamous cell carcinoma,[25] indicating the unique role of interferon‐induced T cells in promoting ESCC metastasis. The gene discussed is IFIT3; the disease is neoplasm.