Pericytes are distributed from 2.34% of fibroblasts in normal tissue to 19.51% of primary tumor fibroblasts with the upregulation of genes related to cell migration and proliferation of vascular associated smooth muscle cell, and to 48.07% of fibroblasts at metastatic lymph nodes characterized by the activation of angiogenesis related genes (LUM and SPP1), suggesting that the accumulation of pericytes might promote the tumor growth and metastasis (Figure 4c,d). This evidence concerns the gene SPP1 and neoplasm.