GSEA analysis demonstrated that genes belonging to the TFEB-regulated Coordinated Lysosomal Expression and Regulation (CLEAR) network22,23 are upregulated in cell lines representing high-grade bladder cancers as compared to cell lines representing low-grade bladder cancers (Fig. 3E) supporting the hypothesis that TFEB is active. The gene discussed is TFEB; the disease is urinary bladder carcinoma.