For example, in mud crab Scylla paramamosain, the differentially expressed miRNAs are mainly related to changes in immune response (including phagocytosis, melanization, and apoptosis) of blood cells42; miR-965 can promote the phagocytosis of shrimp Marsupenaeus japonicus against viral infection by targeting ATG5 (autophagy-related 5) gene of shrimp43; miR-133 promotes V. splendidus to participate in TLR cascade regulation of sea cucumber Apostichopus japonicus phagocyte through AjIRAK-1 targeting34. This evidence concerns the gene ATG5 and viral infectious disease.