Histochemistry of tumor sections also showed that deletion of UGCG significantly reduced levels of phosphorylated MEK (p-MEK) and p-ERK but did not affect levels of ribosomal p-S6 and p-AKT, indicative of selective downregulation of RAF-MEK-ERK signaling cascades (Fig. S8). This evidence concerns the gene AKT1 and neoplasm.