That Wee1 targeting is an efficient approach to radio- and chemosensitize EGFRvIII− GBM cells, has already been suggested by Mir et al., who showed that EGFRvIII− GBM cells can be pushed into mitotic catastrophe by Wee1 inhibition after DNA damaging radio- or chemotherapy. The gene discussed is WEE1; the disease is glioblastoma.