Compared with NC mice, the CIA + Dgal group showed 77 up-regulated proteins and 67 down-regulated proteins (Fig. 2C), mainly enriched in regulation of actin cytoskeleton, phagosome, neutrophil extracellular trap formation, focal adhesion, Rap1 signaling pathway, human papillomavirus infection, PI3K-Akt signaling pathway (Fig. 2D and Additional file 3). The gene discussed is AKT1; the disease is human papilloma virus infection.