The risk factor analysis revealed that female gender, age > 60 years, presence of preoperative gastrointestinal symptoms, complications of hypertension and diabetes, use of laparoscopic pancreaticoduodenectomy (LPD) as the operation method, intraoperative hemorrhage > 500 mL and blood transfusion; preoperative neutrophil count ≥ 6.3 × 109/L; PT ≤ 9 s, APTT of 23–38 s, AST/ALT > 1, and TBIL > 22 μmol/L may be the risk factors for VTE in patients undergoing PD. The gene discussed is GPT; the disease is Hypertension.