To minimize confounding factors of PSA level and PSA density in two groups, CMH test was performed, showing that the cancer detection rate in TR group was still higher than in TP group both when adjusting with PSA level (OR: 1.529, 95% CI: 1.036–2.255, p = 0.032), or when adjusting with PSA density (OR: 1.514, 95% CI: 1.030–2.226, p = 0.035). Here, KLK3 is linked to cancer.