KLK3 and Familial prostate cancer: Among 410 patients diagnosed with prostate cancer in our hospital (180 patients whose prostate volume was not available, or with PSA ≥ 100 ng/mL were excluded from the study), patients with PSA levels > 20 ng/mL accounted for 68.3% (280/410), patients with ISUP grade 4–5 accounted for 66.3% (272/410), and patients with T3 and T4 stages accounted for 67.2% (197/293).