伴ASXL1突变非M3型AML患者初诊时WBC、异常细胞占有核细胞比例均高,CR1率低,OS及PFS时间短。ASXL1突变患者中高VAF、碱基重复和替换突变与预后不良有关,异常细胞占有核细胞比例高、复杂核型和TET2突变均为影响预后的独立危险因素。. The gene discussed is ASXL1; the disease is acute myeloid leukemia.