The median number of mutation of LT group was 1(1, 3), that in non-LT group was 1(0, 2),which had a statistical difference(P=0.003).At the time of the initial diagnosis of MDS, the LT group had higher rates of the TP53 mutation(P=0.034), DNMT3A mutation(P=0.026), NRAS mutation(P=0.027)and NPM1 mutation(P=0.017). The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.