,79, 80, 81 Paracrine signaling involving the release of chemokine (C-C motif) ligand (CCL) 5, CXCL11, HGF, and follistatin like 1 (FSTL1) is exploited by CAFs to facilitate pulmonary metastasis in HCC.51 This evidence concerns the gene FSTL1 and hepatocellular carcinoma.