,105, 106, 107, 108, 109, 110 Notably, CLCF1 and endosialin are primarily expressed on HCC CAFs and associated with poor clinical outcome in HCC, whereas heightened expression of FAP predicts poor prognosis in iCCA patients, suggesting the clinical relevance of these signaling cascades.86 Here, CD248 is linked to hepatocellular carcinoma.