And results showed that proliferation of all groups was inhibited because of N-Myc knockdown, and the inhibition of CPI-637 did not further slowdown the cell proliferation, which further supported the theory that p300 modulated the proliferation of MYCN-amplified NB cells via regulating N-Myc expression (supplemental Fig. S3, A–D). The gene discussed is EP300; the disease is neuroblastoma.