MAPK8 and triple-A syndrome: In this study, we focused on the p38 and JNK signaling pathways because mounting evidence suggests that p38 and JNK are activated in AAA patients and mice, and the p38 and JNK pathways are associated with MMP‐9 and MMP‐2 production (DiMusto et al., 2012; Dodd et al., 2011; Gao, Gao, et al., 2021; Yoshimura et al., 2005).