MAPT and Alzheimer disease: As shown in Figure 6B–H, the basal levels of phospho‐tau Thr181 [Hippocampus: F(1, 20) = 39.82, p < 0.0001; Cortex: F(1, 20) = 43.37, p < 0.0001] and Ser396 [Hippocampus: F(1, 20) = 285.9, p < 0.0001; Cortex: F(1, 20) = 199.3, p < 0.0001] were significantly higher in the AD mice than in the WT mice according to two‐way ANOVA.