A cohort of 9‐month‐old APP/PS1 (AD) mice and wild‐type (WT) mice received intraperitoneal injections of vehicle (5% Tween 80 in 0.9% normal saline) or apicidin (3.5 mg/kg in 5% Tween 80 in 0.9% normal saline) every 2 days for two mo. This evidence concerns the gene APP and Alzheimer disease.