Since multiple molecular mechanisms, including MMPs, vascular endothelial growth factor receptor (VEGFR1), and hypoxia‐inducible factor (HIF)‐1α, have been reported to participate in VM formation, which is linked to tumor invasion and metastasis [46, 47], we attempted to confirm whether the aberrant expression of L1 is associated with the regulation of VM formation in glioma. The gene discussed is HIF1A; the disease is neoplasm.