Furthermore, after examining L1 expression in miR‐143‐3p‐pertubed glioma cells, we found that the activation of the L1/HK2 cascade failed to regulate the expression of L1 in glioma cells (Fig. S3E), suggesting that the regulation of miR‐143‐3p or HK2 can only affect tumor invasion and VM formation, but not be sufficient to regulate L1 expression through a positive feedback regulatory loop in glioma cells. The gene discussed is HK2; the disease is neoplasm.