HK2 and central nervous system cancer: To elucidate the potential roles of the L1/HK2 cascade in glioma invasion and VM formation, we activated or blocked the L1/HK2 cascade by inhibiting the expression of miR‐143‐3p or HK2 using an miR‐143‐3p inhibitor or HK2 siRNAs (siHK2‐1 and siHK2‐2) in U87, T98, and GBM1 glioma cell lines, respectively (Fig. S3A,B).