To explore how DICER1‐AS1 activates the MAPK/ERK pathway, we investigated the localization of DICER1‐AS1 in CRC cells; it is mainly distributed in the cytoplasm according to RT–qPCR assays of cytoplasmic and nuclear RNA in CRC cells, FISH assays, and reliable public online databases. The gene discussed is DICER1; the disease is colorectal carcinoma.