We confirmed that high DICER1‐AS1 expression increased phosphorylated ERK1/2 protein levels by western blotting assays, and the addition of ERK inhibitors partially alleviated these effects, suggesting that DICER1‐AS1 activates the MAPK/ERK pathway to promote tumorigenesis in CRC. The gene discussed is DICER1; the disease is colorectal carcinoma.