Moreover, this was the first study to uncover the interaction of MAPK1 with miR‐650 and show that DICER1‐AS1 promotes CRC cell proliferation by competitively sponging miR‐650 to upregulate MAPK1 expression, promoting ERK1/2 phosphorylation, and activating the MAPK/ERK pathway. This evidence concerns the gene PTGDR and colorectal carcinoma.