To explore how DICER1‐AS1 activates the MAPK/ERK pathway, we investigated the localization of DICER1‐AS1 in CRC cells; it is mainly distributed in the cytoplasm according to RT–qPCR assays of cytoplasmic and nuclear RNA in CRC cells, FISH assays, and reliable public online databases. This evidence concerns the gene MAPK1 and colorectal carcinoma.