Our previous database analysis confirmed that TRMT6/TRMT61A, a methylase complex composed of the catalytic subunit TRMT61A and the binding subunit TRMT6, is responsible for m1A58 modification of tRNA and can specifically identify m1A sites in the 5’UTR sequence of mRNA that conforms to the “GUUCRA” motif [16, 17], and was closely related to the progression and prognosis of HCC patients. The gene discussed is TRMT6; the disease is hepatocellular carcinoma.