Recent results have shown that miR-181 containing MSC-derived exosome [108] and also superoxide dismutase 3 (SOD3) overexpressing MSCs [109] can promote claudin-1 and ZO-1 expression and consequently upgrade intestinal barrier function, conferring the unique competencies of MSCs-based cell therapies to support intestinal barrier in IBD patients. The gene discussed is SOD3; the disease is inflammatory bowel disease.