At 3 h post infection the IL-21 level was 60% which decreased significantly at 6 h (30%, p < 0.0001), 12 h (27%, p < 0.0001) and finally decreased to the level 20% (p < 0.0001) at 24 h post infection (Fig. 6) when compared to the level expressed at 0 h post JEV infection. The gene discussed is IL21; the disease is infection.