GFAP and Alzheimer disease: We found a statistically significant effect of genotype (LME, p = 2.05e − 6) demonstrating decreased astrogliosis in the controls 44.17 (95% CIs: 31.26–57.08) versus the AD mice that in the cortex showed higher GFAP-signal levels of 62.62 (95% CIs: 48.15–77.09).