Of note, global functional deficits in brain networks as observed using rsfMRI at advanced stages of AD in humans [35, 36] are consistent with measurements in several transgenic EOAD mouse models [37, 38] and the outcome of our recent work where we detected impairments in rsfMRI network integrity in a mature-onset Tet-Off APP mice [39]. The gene discussed is APP; the disease is Alzheimer disease.