Patients in PAC1 and low Pyrsig score group showed higher infiltration of activated memory CD4+ and CD8+ T cells, gamma delta T cells and activated NK cells, suggesting a better prognosis and anti-tumor immunity in OC development, we also validated GSDMD and GZMB were significantly associated infiltration of CD8+ T cells in OC with IHC. This evidence concerns the gene CD4 and neoplasm.