In conclusion, we comprehensively explored genetic variations and transcriptional patterns of pyroptosis in 1332 OC samples, and uncovered their potential role on prognostic value, clinicopathological characteristics and tumor immune microenvironment of ovarian cancer, we further revealed the superior advantage of Pyrsig score in targeted therapy and immunotherapy, and expressions of GSDMD and GZMB were associated with immune infiltration. Here, GSDMD is linked to ovarian cancer.