CASP3 and neoplasm: Furthermore, the results of immunohistochemistry analysis of tumors (Fig. 7G) indicated that THC inhibited the proliferation of nuclear Ki-67-positive cells, enhanced the expression of cleaved caspase-3 to induce cell apoptosis, reduced the expression of MMP-2 to inhibit metastasis, and downregulated the expression levels of NF-κB in tumor sections.