Consistent with the anti-PD1-response of B16F10, higher frequencies of CD206+ cells were observed in responders of MC38-Luc models (Fig. 5a, b); furthermore, the accumulation of [68Ga]Ga-MSA nanoparticle of the responders was higher than non-responders and appeared throughout the tumor (Fig. 5c, d). The gene discussed is MRC1; the disease is neoplasm.