For instance, as a result of environmental and physiological stress, such as imposed by hypertension, leads to an imbalance in gene regulation by acetylation and deacetylase [23]; in addition, under cellular stress, the Eukaryotic Initiation Factor 2 (eIF2α) phosphorylation represses global translation coincident with a preferential translation of Activating Transcription Factor 4 (ATF4), a master regulator controlling the transcription of key genes essential for adaptative functions [29, 30]. The gene discussed is ATF4; the disease is hypertensive disorder.