However, the TFE3 expression is not specific for this tumor, as it has previously been reported in other tumors of different histogenesis (including the MiT family translocation-associated renal cell carcinoma, perivascular epithelioid cell tumors, subset of epithelioid hemangioendotheliomas, and some others) [12–14]. This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.