By stratifying the RETNLB expression levels obtained from biopsies of CRC patients as a function of the TNM classification, we noted a significantly progressive reduction with increasing TNM grade (p < 0.01 in TNM1 vs TNM2, p < 0.01 in TNM1 vs TNM3, p < 0.001 in TNM1 vs TNM4) (p = 0.04, r = −0.08) (Fig. 1c, d). The gene discussed is RETNLB; the disease is colorectal carcinoma.