Even though STAT3 expression was not significantly altered in tumor (Fig. S4A), the STAT3 mutation was strongly correlated to the overall survival rate of lung cancer patients (Fig. S4B), and hyperphosphorylation of STAT3 was extensively found in lung adenocarcinoma (Fig. S4G), suggesting that suppression of its phosphorylation provides promising therapeutic approach31,32. Here, STAT3 is linked to neoplasm.