ACE and endocarditis: Many genes associated with biofilm formation were identified such as two aggregation substances (agg and prgB), endocarditis and biofilm-associated pili genes (ebpA, ebpB, ebpC), collagen adhesion precursor (ace), three proteolytic processing of a quorum-sensing system signal molecule precursors (fsrA, fsrB and fsrC), accessory regulator protein (agrBfs), sugar-sensing transcriptional regulator (bopD), serine protease (sprE) and two genes for sortase assembled pili (srtA and strC).