Moreover, a recent study reported that activation of hepatic leptin signaling improved hyperglycemia by degrading MARK phosphatase-3 (also known as dual specificity phosphatase 6, DUSP6) and subsequent repressing Foxo1-mediated gluconeogenesis pathway27, indicating Gm19619 may promote the hepatic gluconeogenesis by repressing the hepatic leptin signaling. The gene discussed is FOXO1; the disease is Hyperglycemia.