We found that the most significantly different features in pCR cases against residual tumor cases are highly consistent with those identified by machine learning methods, such as Lymph: CD163 ratio (adjusted P-value = 0.0163) and Lymph: CD8 ratio (adjusted P-value = 0.0163), two top-ranked favorable features for HER2+ cases, which were identified by both univariate analysis and machine learning model. This evidence concerns the gene CD8A and neoplasm.