Overall, germline RDVs associated with TMB in: (i) DDR, CPD and SCD genes in colon cancer; (ii) DDR genes in kidney clear cell and cervical cancers; (iii) CPD genes in kidney papillary cell cancer; (iv) SCD genes in stomach and ovarian cancers; and (v) FA genes in breast, cervical, ovarian and stomach cancers. Here, SCD is linked to colonic neoplasm.