HG-induced Nrg1 overexpression was abolished by silencing of P300, Cbp, and Setd1A genes in Met1 cancer cells compared with scrambled (Scrb) shRNA or shRNA non-treated control cells (Fig. 2l), indicating that P300, CBP, and SETD1A may be associated with Nrg1 enhanceosome assembly. The gene discussed is SETD1A; the disease is cancer.