We initially produced a pilot library targeting 98 chromatin regulator genes and screen pairwise combinations all-by-all in THP-1, a mixed-lineage leukemia (MLL)-AF9 rearranged monocytic leukemia, and Reh, a TEL-AML1 carrying lymphocytic leukemia (Supplementary Fig. 2a-c). The gene discussed is KMT2A; the disease is lymphoid leukemia.